abstract：:Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...

journal_title：Neuron

authors： Hsu SC,Hazuka CD,Roth R,Foletti DL,Heuser J,Scheller RH

更新日期：1998-06-01 00:00:00

abstract：:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...

journal_title：Neuron

authors： García-Añoveros J,García JA,Liu JD,Corey DP

更新日期：1998-06-01 00:00:00

abstract：:Dendritic spines have been proposed as primary sites of synaptic plasticity in the brain. Consistent with this hypothesis, spines contain high concentrations of actin, suggesting that they might be motile. To investigate this possibility, we made video recordings from hippocampal neurons expressing actin tagged with g...

journal_title：Neuron

authors： Fischer M,Kaech S,Knutti D,Matus A

更新日期：1998-05-01 00:00:00

abstract：:Although motion-sensitive neurons in macaque middle temporal (MT) area are conventionally characterized using stimuli whose velocity remains constant for 1-3 s, many ecologically relevant stimuli change on a shorter time scale (30-300 ms). We compared neuronal responses to conventional (constant-velocity) and time-var...

journal_title：Neuron

authors： Buracas GT,Zador AM,DeWeese MR,Albright TD

更新日期：1998-05-01 00:00:00

abstract：:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...

journal_title：Neuron

authors： Giniger E

更新日期：1998-04-01 00:00:00

abstract：:Voltage-gated calcium channels are well characterized at neuronal somata but less thoroughly understood at the presynaptic terminal where they trigger transmitter release. In order to elucidate how the intrinsic properties of presynaptic calcium channels influence synaptic function, we have made direct recordings of t...

journal_title：Neuron

authors： Forsythe ID,Tsujimoto T,Barnes-Davies M,Cuttle MF,Takahashi T

更新日期：1998-04-01 00:00:00

abstract：:We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...

journal_title：Neuron

authors： Milone M,Wang HL,Ohno K,Prince R,Fukudome T,Shen XM,Brengman JM,Griggs RC,Sine SM,Engel AG

更新日期：1998-03-01 00:00:00

abstract：:Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasin...

journal_title：Neuron

authors： McNeil GP,Zhang X,Genova G,Jackson FR

更新日期：1998-02-01 00:00:00

abstract：:While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...

journal_title：Neuron

authors： Frade JM,Barde YA

更新日期：1998-01-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis desensitize in response to prolonged or repeated agonist exposure, and evidence suggests that this involves activation of protein kinase C (PKC). The present studies were undertaken to determine if cloned mGluR5 undergoes similar PKC-medi...

journal_title：Neuron

authors： Gereau RW 4th,Heinemann SF

更新日期：1998-01-01 00:00:00

abstract：:To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene. VMAT2-/- mice move little, feed poorly, and die within a few days after birth. Monoamine cell groups and their projections are indistinguishable from those of wild-type li...

journal_title：Neuron

authors： Fon EA,Pothos EN,Sun BC,Killeen N,Sulzer D,Edwards RH

更新日期：1997-12-01 00:00:00

abstract：:We have cloned from the receptor epithelium of the chick cochlea a family of alternatively spliced cDNAs derived from cslo, which encodes a Ca2+-activated K+ channel like those shown to help determine the resonant frequency of electrically tuned hair cells. Our results from PCRs using template RNAs from both tonotopic...

journal_title：Neuron

authors： Navaratnam DS,Bell TJ,Tu TD,Cohen EL,Oberholtzer JC

更新日期：1997-11-01 00:00:00

abstract：:Measuring electrical activity in large numbers of cells with high spatial and temporal resolution is a fundamental problem for the study of neural development and information processing. To address this problem, we have constructed a novel, genetically encoded probe that can be used to measure transmembrane voltage in...

journal_title：Neuron

authors： Siegel MS,Isacoff EY

更新日期：1997-10-01 00:00:00

abstract：:The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...

journal_title：Neuron

authors： Xu M,Koeltzow TE,Santiago GT,Moratalla R,Cooper DC,Hu XT,White NM,Graybiel AM,White FJ,Tonegawa S

更新日期：1997-10-01 00:00:00

abstract：:Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...

journal_title：Neuron

authors： Deiner MS,Kennedy TE,Fazeli A,Serafini T,Tessier-Lavigne M,Sretavan DW

更新日期：1997-09-01 00:00:00

abstract：:We have cloned a Kv2 potassium channel from squid optic lobe termed sqKv2. Multiple overlapping sqKv2 cDNA clones differed from one another at specific positions by purine transitions. To test whether the purine transitions were generated by RNA editing, we compared a 360 nucleotide genomic sequence with corresponding...

journal_title：Neuron

authors： Patton DE,Silva T,Bezanilla F

更新日期：1997-09-01 00:00:00

abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

journal_title：Neuron

authors： Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

更新日期：1997-08-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) have long been associated with proliferation in non-neural cells, although they are also expressed in postmitotic neurons. We demonstrate that insulin-like growth factor-1 (IGF-1) induces within seconds a large, tyrosine-kinase-dependent increase in calcium channel currents in cerebell...

journal_title：Neuron

authors： Blair LA,Marshall J

更新日期：1997-08-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...

journal_title：Neuron

authors： Hynes M,Stone DM,Dowd M,Pitts-Meek S,Goddard A,Gurney A,Rosenthal A

更新日期：1997-07-01 00:00:00

abstract：:Following alpha-latrotoxin application to cerebellar slices, bursts of miniature IPSCs (mIPSCs) were observed in interneurons of the molecular layer. Within bursts, mIPSCs had homogeneous amplitudes with a narrow Gaussian distribution. Analysis of successive event amplitudes revealed an interaction between consecutive...

journal_title：Neuron

authors： Auger C,Marty A

更新日期：1997-07-01 00:00:00

abstract：:alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of al...

journal_title：Neuron

authors： Krasnoperov VG,Bittner MA,Beavis R,Kuang Y,Salnikow KV,Chepurny OG,Little AR,Plotnikov AN,Wu D,Holz RW,Petrenko AG

更新日期：1997-06-01 00:00:00

abstract：:The hippocampus and its associated structures play a key role in human memory, yet the underlying neuronal mechanisms remain unknown. Here, we report that during encoding and recognition, single neurons in the medial temporal lobe discriminated faces from inanimate objects. Some units responded selectively to specific...

journal_title：Neuron

authors： Fried I,MacDonald KA,Wilson CL

更新日期：1997-05-01 00:00:00

abstract：:C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that a...

journal_title：Neuron

authors： Iwasaki K,Staunton J,Saifee O,Nonet M,Thomas JH

更新日期：1997-04-01 00:00:00

abstract：:Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the apparent diffusion coefficient (D(app)) of Ca2+, whereas mobile buffers contribute to Ca2+ redistribution. To estimate the impact of the expression of specific Ca2+-b...

journal_title：Neuron

authors： Gabso M,Neher E,Spira ME

更新日期：1997-03-01 00:00:00

abstract：:The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...

journal_title：Neuron

authors： Kane NS,Robichon A,Dickinson JA,Greenspan RJ

更新日期：1997-02-01 00:00:00

abstract：:Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...

journal_title：Neuron

authors： Tse FW,Tse A,Hille B,Horstmann H,Almers W

更新日期：1997-01-01 00:00:00

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:We measured amygdala activity in human volunteers during rapid visual presentations of fearful, happy, and neutral faces using functional magnetic resonance imaging (fMRI). The first experiment involved a fixed order of conditions both within and across runs, while the second one used a fully counterbalanced order in ...

journal_title：Neuron

authors： Breiter HC,Etcoff NL,Whalen PJ,Kennedy WA,Rauch SL,Buckner RL,Strauss MM,Hyman SE,Rosen BR

更新日期：1996-11-01 00:00:00

abstract：:Molecular determinants of Ca2+ channel responsiveness to inhibition by receptor-coupled G proteins were investigated in Xenopus oocytes. The inhibitory response of alpha1B (N-type) channels was much larger than alpha1A (P/Q-type) channels, while alpha1C (L-type) channels were unresponsive. Differences in both degree a...

journal_title：Neuron

authors： Zhang JF,Ellinor PT,Aldrich RW,Tsien RW

更新日期：1996-11-01 00:00:00

abstract：:We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic ...

journal_title：Neuron

authors： Prokop A,Landgraf M,Rushton E,Broadie K,Bate M

更新日期：1996-10-01 00:00:00

abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...

journal_title：Neuron

authors： Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

更新日期：1996-10-01 00:00:00

abstract：:beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...

journal_title：Neuron

authors： Thomas MJ,Moody TD,Makhinson M,O'Dell TJ

更新日期：1996-09-01 00:00:00

abstract：:Memory distortions and illusions have been thoroughly documented in psychological studies, but little is known about the neuroanatomical correlates of true and false memories. Vivid but illusory memories can be induced by asking people whether they recall or recognize words that were not previously presented, but are ...

journal_title：Neuron

authors： Schacter DL,Reiman E,Curran T,Yun LS,Bandy D,McDermott KB,Roediger HL 3rd

更新日期：1996-08-01 00:00:00

abstract：:Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...

journal_title：Neuron

authors： Michaelidis TM,Sendtner M,Cooper JD,Airaksinen MS,Holtmann B,Meyer M,Thoenen H

更新日期：1996-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more molecular specificity than is possible using pharmacological approaches. ...

journal_title：Neuron

authors： Patterson SL,Abel T,Deuel TA,Martin KC,Rose JC,Kandel ER

更新日期：1996-06-01 00:00:00

abstract：:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...

journal_title：Neuron

authors： Cantrell AR,Ma JY,Scheuer T,Catterall WA

更新日期：1996-05-01 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) can be regulated by synaptic activity and could therefore be involved in activity-dependent control of neuronal growth. We tested whether increased CaMKII activity in postsynaptic optic tectal neurons can modify the development of retinotectal axons in Xenopus. T...

journal_title：Neuron

authors： Zou DJ,Cline HT

更新日期：1996-03-01 00:00:00

abstract：:The mesolimbic system is known to play a role in self-administration of opioids and psychostimulants. Although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination ...

journal_title：Neuron

authors： Bonci A,Williams JT

更新日期：1996-03-01 00:00:00